Cardiothoracic 
Surgery 
Expert

SCIENTIFIC AND ACADEMIC CONTRIBUTIONS

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Professor Ohri has a national and international reputation for scientific scholarship. Throughout his 22-year tenure as a Consultant Cardiac Surgeon he has also held a joint Senior Lecturer Position with the University of Southampton. Professor Ohri was awarded a chair as Professor of Cardiac Surgery by the university in 2019 as recognition of his ongoing scientific endeavour.

Professor Ohri’s undertook post-doctoral research at the Royal Postgraduate Medical School, Hammersmith Hospital as British Heart Foundation Fellow. He was awarded his post Bachelor of Medicine higher doctorate MD for his research into the pathophysiology of cardiopulmonary bypass and it’s impact on the gut. As a result, his ongoing research interests include the pathophysiology of cardiopulmonary bypass, bicuspid aortic valve disease and aortopathy, the impact of diabetes on the aortic valve and transcatheter interventions for valvular heart disease.

He has supervised the research of numerous students and cardiac Surgical trainees, 9 of whom have successfully been awarded their own higher doctorates. He has been the recipient of 26 research grants and Principal Investigator of 31 studies.

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Professor Ohri has authored 4 books on cardiac surgery and published more than 160 articles and numerous abstracts in leading scientific journals. A full list of his publications can be found below.

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General Surgery

1. The use of the intraluminal bypass tube in the management of the obstructed colon.

2.  Reappraisal of partial ileal bypass surgery for the treatment of familial hypercholesterolaemia.

3.  Primary rectal lymphoma and malignant lymphomatous polyposis. Two cases illustrating current methods in diagnosis and management.

4.  The management of postoperative chylous ascites.

5.  Osteolytic lesions in chronic myelomonocytic leukaemia.

6. Foreign body perforation of the ileum.

7. Hepato-cellular carcinoma and treatment with cyproterone acetate.

8. The role of intraoperative enteroscopy in obscure gastrointestinal bleeding of small bowel origin.

9. Modified Ramstedt’s pyloromyotomy for the treatment of infantile hypertrophic Pyloric stenosis.

10. Drug induced colonic pseudo-obstruction.

11. Metastatic angiosarcoma of the ovary.

12. Pediatric stirrups for anorectal surgery.

13. Jejunal vascular malformation in Klippel Trenaunay syndrome.

14. A case of primary synchronous bilateral separate male breast carcinoma.

15. The relationship between clinical staging, oestrogen receptor status and silver-binding nucleolar organiser regions (AgNOR) in breast carcinoma.

16. The intraoperative localisation of the obscure bleeding site using fluorescein.

17. Value of scintigraphic localisation of obscure gastrointestinal bleeding.

18. Ileal conduit for reconstruction of the duodenum following radical resection for malignant duodeno-colic fistula.

19. Evidence for thyroid development from the fourth branchial pouch.

Thoracic Surgery

1. Palliative intubation for dysphagia using the Atkinson tube in patients with Carcinoma of the esophagus.

2. Cardiac torsion following partial pericardectomy.

3. Early & late outcome following diagnostic thoracoscopy & talc pleurodesis.

4. Aorto-oesophageal fistula complicating oesophago-gastrectomy for carcinoma of The oesophagus.

5. The folded lung: a masquerader of malignancy.

6. Primary repair of iatrogenic esophageal perforations & Boerhaaves syndrome.

7. Acquired segmental emphysema: the enlarging spectrum of Swyer/James – Macleod's syndrome.

8. Homograft as a conduit for superior vena cava syndrome.

9. Thoracoscopic debridement of empyema thoracis.

10. Iatrogenic oesophageal perforations: a clinical review.

11. Primary esophageal repair for Boerhaave’s syndrome.

Cardiac Surgery

1. Gastrointestinal damage following cardiopulmonary bypass.

2. The pathophysiology of nephrourological complications following cardiopulmonary bypass.

3. Intra-abdominal complications following cardiopulmonary bypass.

4. The pattern of substrate metabolism by mammalian lung & it’s implication for Defence against free radical oxidative damage.

5. Early and long term results of re-operation for coronary artery disease.

6. Angiosarcoma of the heart causing cardiac rupture: a rare cause of hemopericardium.

7. The effects of cardiopulmonary bypass on the immune system.

8. Cardiopulmonary bypass impairs small intestinal transport & increases gut permeability.

9. The effect of intestinal hypoperfusion on intestinal absorption and permeability during cardiopulmonary bypass.

10. The effects of cardiopulmonary bypass upon gut mucosal blood flow, oxygen Utilization and intramucosal pH.

11. The effect of cardiopulmonary bypass on gastric and colonic mucosal perfusion: a tonometric assessment.

12. Enhanced excretion of urinary LTE4 in coronary artery disease patients and Following cardiopulmonary bypass.

13. Left ventricular function and coronary artery disease progression early after coronary bypass grafting.

14. Carcinoid heart disease - The risks of biological valve replacement.

15. Endotoxaemia during cardiopulmonary bypass: measurement using a modified Limulus amoebocyte lysate assay.

16. Gastrointestinal injury following cardiopulmonary bypass.

17. A genetically engineered serine protease inhibitor for limiting cardiopulmonary bypass related blood loss - a step towards tailored hemostatic pharmacotherapy.

18. The systemic inflammatory response & the splanchnic bed during cardiopulmonary Bypass.

19. Magnetic resonance imaging in redo coronary surgery.

20. The relationship between anaesthetic uptake and cardiac output.

21. Nitric oxide activity in cardiopulmonary bypass patients.

22. The effect of cardiopulmonary bypass perfusion protocols upon gut tissue Oxygenation and blood flow.

23. Hepatic blood flow during cardiopulmonary bypass: the effect of temperature and pulsatility.

24. Autotransfusion of washed shed mediastinal fluid decreases the requirement for autologous blood transfusion following cardiac surgery: a prospective randomized trial.

25. Tricuspid valve replacement: bioprostheses are preferable.

26. Vacuum-assisted closure to treat deep sternal wound infection following cardiac surgery.

27. Novel application of vacuum assisted closure technique to the treatment of Sternotomy wound infection.

28. Mitral regurgitation secondary to ruptured papillary muscle.

29. Off-pump coronary artery bypass grafting.

30. A millennium survey of myocardial revascularisation in the United Kingdom: to pump or not to pump?

31. Novel approach to bleeding in patients undergoing cardiac surgery with liver dysfunction.

32. Endoscopic vein harvesting with the aid of carbon dioxide insufflation.

33. Coronary Surgery for the 21st century? Off-pump coronary artery bypass grafting.

34. Transventricular cannulation of the aorta: a useful technique in acute aortic dissection.

35. A genetically engineered human Kunitz protease inhibitor with increased Kallikrein inhibition in an ovine model of cardiopulmonary bypass. inhibition in an ovine model of cardiopulmonary bypass.

36. Autotransfusion decreases blood usage following cardiac surgery: a prospective randomized trial.

37. Complete myocardial revsacularisation in severe arteriopathy.

38. Retropericardial hematoma: Pitfall in Beating Heart Coronary Surgery.

39. Ptosis postcardiac surgery: A case of pituitary apoplexy.

40. Type B aortic dissection & right hemothorax.

41. Off-pump Coronary Surgery.

42. Leukodepletion reduces renal injury in coronary artery revascularisation: a prospective randomized study.

43. Giant left ventricular aneurysm: images in cardiothoracic medicine and surgery.

44. A giant sternal abscess following traumatic sternal fracture.

45. Risk of reoperation for structural failure of aortic and mitral tissue valves.

46. Mitral Valve Surgery for Papillary muscle rupture following acute myocardial infarction.

47. Reflex sympathetic dystrophy: an unusual complication of radial artery graft harvesting.

48. A prospective randomized study to evaluate the renoprotective action of beating heart coronary surgery in low risk patients.

49. Right pleuro-pericardial release: A useful technique in off pump coronary surgery.

50. A prospective randomized study to evaluate splanchnic hypoxia during beating heart and conventional coronary revascularization.

51. A prospective randomized study to evaluate stress response during beating-heart an conventional coronary revascularization.

52. Early prenatal undernutrition causes cardiac hypertrophy and hypertension.

53. Advances in Tissue Engineering: Cell Printing.

54. Fetal origins of coronary heart disease -implications for cardiothoracic surgery.

55. Effects of pre-natal and early post-natal undernutrition on adult internal thoracic artery function.

56. Effect of moderate early gestation undernutrition with or without undernutrition in early postnatal life on internal mammary artery function in sheep.

57. Gastrointestinal dysfunction following cardiac surgery.

58. Carney Complex.

59. Contained intra-ventricular rupture of giant circumflex coronary aneurysm.

60. Bivalirudin anticoagulation for cardiopulmonary bypass.

61. Impact of surgeon-specific data reporting on surgical training.

62. Statin Treatment in Female Mice Has Sex Specific Effects on Cardiovascular Risk Factors and Circulating Endothelial Progenitor Cells in Their Offspring.

63. Statin therapy improves blood pressure and lipid profiles in hypercholesterolemic mothers but not C-reactive proteins levels or endothelial progenitor cell expression.

64. Non-bacterial thrombotic endocarditis.

65. Lung cancer masquerading as prosthetic valve endocarditis.

66. Antithrombotic therapy after bioprosthetic aortic valve replacement: ACTION Registry survey results.

67. Statin treatment in hypercholesterolemic pregnant mice reduces cardiovascular risk factors in their offspring.

68. Cardiac Surgery during Pregnancy.

69. Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function.

70. Early Prosthetic Valve Failure in a Patient With Rheumatoid Arthritis.

71. Video-assisted cardioscopy in the repair of persistent mitral para-prosthetic leak.

72. Long-term maternal high fat feeding from weaning through pregnancy and lactation predisposes to hypertension, raised plasma lipids and fatty liver in mice.

73. Improved technique of nitinol sternal clip application.

74. Thyroid function during coronary surgery with and without cardiopulmonary bypass.

75. Does the use of intraoperative cerebral regional oxygen saturation monitoring during cardiac surgery lead to improved clinical outcomes?

76. The use of nitinol clips in cardiac surgery: A new method of sternal closure.

77. The inflammatory response to miniaturized extracorporeal circulation: a review of the literature.

78. Mid-term evaluation of Sorin Soprano bioprostheses in patients with a small aortic annulus £ 20mm.

79. Myocardial protection during reoperative cardiac surgery: early experience with a new technique.

80. Traumatic fracture of nitinol thermoreactive sternal clips.

81. Aortic root replacement using Biovalsalva prosthesis in comparison to a ‘handsewn’ composite bioprosthesis.

82. Hemodynamic advantages of right heart decompression during off-pump surgery.

83. Early and late clinical outcomes for pulmonary embolectomy after massive pulmonary embolism.

84. Mini extracorporeal circuit cardiopulmonary bypass system: A Review.

85. Left ventricular true and false with true aneurysms identified by cardiovascular magnetic resonance.

86. Aneurysm of arteria lusoria presenting as cardiac dyspnea.

87. Fatal late prosthetic aortic valve endocarditis

88. Extra-anatomic aorto-femoral graft for acute limb ischemia after type A aortic dissection repair.

89. Long-term outcome following repair of acute type A dissection after previous cardiac surgery.

90. Unidentified retained inferior vena cava myxoma detected by intra-operative trans-oesophageal echocardiography.

91. An unusual complication of hemostatic packing to control bleeding during cervical mediastinoscopy and an off-pump approach for later exploration of the superior vena caval injury.

92. Long-term outcomes in octagenarians following aortic valve replacement.

93. Aortic valve replacement in patients with previous coronary artery bypass grafting: 10-years experience.

94. Outcome after redo-mitral valve replacement in adult patients: a 10-year single-centre experience.

95. Aortic root and hemi-arch replacement in osteogenesis imperfecta.

96. Repair of acute type A aortic dissection: results in 100 patients.

97. The outcomes of triple valve surgery; 11 year experience.

98. Right ventricular blood cyst causing outflow obstruction in an adult.

99. Symmetrical aortic valve lesions associated with healed thrombus: a unique presentation.

100. The use of nitinol clips for primary sternal closure in cardiac surgery.

101. Heart Failure: the pivitol role of histone deacetylases.

102. Management options for aorto-oesophageal fistula: case histories and review of the literature.

103. Long-term statin administration to dams on high fat diet protects not only them but also their offspring from cardiovascular and metabolic risk factors fed a similar diet post-weaning.

104. Heart Failure: the pivotal role of histone deacetylases.

105. Low-dose acetyl salicylic acid versus oral anticoagulation after bioprosthetic aortic valve replacement. Final report of the ACTION registry.

106. Reliability of different body temperature measurement sites during aortic surgery.

107. Isolated tricuspid valve repair following metastatic tumour resection.

108. The outcomes of triple valve surgery: eleven years’ experience from a single centre.

109. Early in-vivo Hemodynamic comparison of suprannular aortic bioprostheses: Trifecta versus Perimount Magna Ease.

110. Role of topical application of gentamicin containing collagen implants in cardiac surgery.

111. Internal thoracic vein: friend or foe?

112. Central cannulation by seldinger technique: a reliable method in ascending aorta and aortic arch replacement.

113. Acute type A aortic dissection repair in elderly patients.

114. Transapical perfusion for per-arrest salvage during transcutaneous aortic valve implantation.

115. Remote ischemic preconditioning and outcomes of cardiac surgery.

116. Emergency surgical extraction of rotablator from the stent in the left anterior descending artery.

117. Hemodynamic performance of Trifecta  – Single centre experience of 400 patients.

118. Open and closed distal anastomosis for acute type A aortic dissection repair.

119. Use of minimal Invasive extracorporeal circulation in cardiac surgery: principles, definitions and potential benefits. A position paper from the Minimal invasive extra-corporeal Technologies International Society (MiECTiS).

120. Endogenous Reference Genes for Gene Expression Studies on Bicuspid Aortic Valve Associated Aortopathy in Humans.

121. A unique case of "double-orifice aortic valve"-comprehensive assessment by 2-, 3-dimensional, and color Doppler echocardiography.

122. Do external support devices reduce sternal wound complications after cardiac surgery?

123. Initial experience with xenograft bioconduit for the treatment of complex prosthetic valve endocarditis.

124. Mitral valve replacement in severely calcified mitral valve annulus: a 10-year experience.

125. 3 minute review: Transthoracic & Transoesophageal standard views..

126. Feasibility of a novel, synthetic, self-assembling peptide for suture-line haemostasis in cardiac surgery.

127. Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease.

128. Age-related presentation of acute type A aortic dissection.

129. Pericardial calcification: A case report of a three-dimensional disease.

130. Aortic Stenosis Prognostication in Patients with Type 2 Diabetes: Protocol for Testing and Validation of a Biomarker-Derived Scoring System.

131. Prior Percutaneous Coronary Interventions May Be Associated With Increased Mortality After Coronary Bypass Grafting: A Meta-Analysis.

132. Defective NOTCH signalling drives vascular smooth muscle cell death and differentiation in bicuspid aortic valve aortopathy.

133. Defective NOTCH signalling drives increased vascular smooth muscle cell apoptosis and contractile differentiation in bicuspid aortic valve aortopathy: a review of the evidence and future directions.

134. Real-world Accuracy of Transthoracic Echocardiography in Diagnosing Bicuspid Aortic Valve Morphology: A Single Center UK Experience.

135. Transcatheter aortic valve implantation for low-risk aortic stenosis: are we ready?

136. Is Resident Training Safe in Cardiac Surgery?

Published Books

1. KEY TOPICS IN CARDIAC SURGERY

2. KEY QUESTIONS IN ADULT CARDIAC SURGERY

3. KEY TOPICS IN CARDIAC SURGERY, 2nd Edition

4. CARDIAC SURGERY

Book Chapters

1. Preoperative assessment of cardiac surgical patients in ‘Key Topics in Cardiac Surgery’

2. Postoperative complications in ‘Key Topics in Cardiac Surgery’

3. Cellular Cardiomyoplasty in ‘Key Topics in Cardiac Surgery’

4. Atrial Septal Defects in ‘Key Topics in Cardiac Surgery’

5. Conventional Coronary Surgery in ‘Key Topics in Cardiac Surgery’

6. Transcatheter aortic valve implantation

7. Atrial fibrillation

8. Recent advances in the management of Acute Aortic Syndrome.

9. Surgery for Atrial fibrillation

10. Surgical management of acute pulmonary embolism

11. Surgical management of chronic pulmonary embolism

12. Surgical Treatment of atrial fibrillation